At the Institute of Pharmaceutical Sciences (TIPS)’s journal club meeting held online on May 17, 2021, the topic of “Silica-based nanosystems for therapeutic applications in the skin” was presented by M. Keykhaee. In this meeting, the various types of silica nanoparticles with therapeutic applications in different skin diseases were introduced. Take home message of this meeting was that these types of nanosystems can improve treatment efficacy of several drugs and are useful tools for nanomedicine, pharmaceutical sciences and future clinical applications.