12 February 2018, in the journal club meeting the topic, “Pesticides related disorders with respect to Parkinson’s disease” was discussed. Exposure to pesticides is thought to be an important cause of Parkinson's disease. A new study shows that rats chronically treated with the mitochondrial inhibitor rotenone, a common pesticide, develop neuropathological and behavioral symptoms of Parkinsonism. Parkinson's disease (PD) is one of the most common neurodegenerative diseases, affecting almost 1% of the population over 65. Although the symptoms and neuropathology of PD have been well characterized, the underlying mechanisms and causes of the disease are still not clear. It has been reported that chronic administration of rotenone, a widely used pesticide, can induce the major features of PD in rats. This remarkable observation not only provides a new animal model for the study of PD, but will also reinvigorate interest in the possible role of exposure to pesticides and other toxins as a cause of human neurodegenerative disease