19th February 2018, in the journal club meeting the topic, “Role of epigenetic alterations in sepsis" was discussed. Sepsis has been classified among the leading causes of death with no specific etiology or treatment. Increase in health burden in terms of cost, morbidity, and mortality has led to the continuous search for different treatment modalities which involve several targets/approach. Evidence has revealed the involvement of epigenetics in sepsis. Changes in DNA methylation pattern, histone modification, and microRNA regulation have been shown in sepsis models to silence pro-inflammatory genes such TNF-α and interleukins, alter the expression of anti-oxidant enzymes, as well as signaling pathways. Epigenetic processes involving specific enzymes detected in the blood and other body fluids can serve as diagnostic, therapeutic, as well as prognostic tools in sepsis.