Sepsis  and Gene Polymorphisms was discussed in 11/6/2017 meeting.
Sepsis is a systemic inflammatory response syndrome arising from infection. In various settings, mortality rates of patients suffering from sepsis have reached 20–70% . Sepsis-related polymorphism studies have most commonly focused on one or more polymorphisms for specific genes whose protein products are elements of biologic pathways implicated in sepsis. During the past 15 years, approximately 10 million polymorphisms have been identified in the human genome. Studies designed to investigate numerous polymorphisms make use of novel technologies such as DNA microarrays. Polymorphisms of many inflammatory cytokine gene and innate immunity pathways has been shown to play a large role in determining susceptibility to outcome of  complex disease like sepsis. Examination of the association between genetic polymorphisms and sepsis promises to provide clinicians with new tools to evaluate prognosis and aggressively in treating high risk persons and to avoid the use of therapies with adverse effects in treating low risk persons.