23 April 2018, in the journal club meeting the topic, “Signaling pathway Linking Insulin resistance to Type 2 Diabetes mellitus” was discussed. Insulin resistance is a major risk factor for developing type 2 diabetes caused by the inability of insulin-target tissues to respond properly to insulin, and contributes to the morbidity of obesity. Insulin action involves a series of signaling cascades initiated by insulin binding to its receptor, eliciting receptor autophosphorylation and activation of the receptor tyrosine kinase, resulting in tyrosine phosphorylation of insulin receptor substrates (IRSs). Phosphorylation of IRSs leads to activation of phosphatidylinositol 3-kinase (PI3K) and, subsequently, to activation of Akt and its downstream mediator AS160, all of which are important steps for stimulating glucose transport induced by insulin. Vaspin inhibits Tnf-α, methylglyoxal, and high glucose-induced ROS formation and subsequently inhibits cell apoptosis.