20th November 2017, in the journal club meeting the topic, “Stem cells and their use in neurodevelopmental therapies”, was discussed. In the recent years, it has become more evident that the developing and even the adult mammalian central nervous system contains a population of undifferentiated, multipotent cell precursors, neural stem cells, the elastic properties of which might be of advantage for the design of more effective therapies for many neurological diseases. In the presentation, the recent progress in establishing rodent and human clonal neural stem cell lines was highlighted and also their biological properties, and how these cells can be utilized to a correct variety of defects, with prospects for the near future to harness their behavior for neural stem cell-based treatment of diseases in humans.